Intertumoral Heterogeneity in SCLC Is Influenced by the Cell Type of Origin.

Cancer Discov 2018 10 18;8(10):1316-1331. Epub 2018 Sep 18.

Cancer Biology Program, Stanford University, Stanford, California.

The extent to which early events shape tumor evolution is largely uncharacterized, even though a better understanding of these early events may help identify key vulnerabilities in advanced tumors. Here, using genetically defined mouse models of small cell lung cancer (SCLC), we uncovered distinct metastatic programs attributable to the cell type of origin. In one model, tumors gain metastatic ability through amplification of the transcription factor NFIB and a widespread increase in chromatin accessibility, whereas in the other model, tumors become metastatic in the absence of NFIB-driven chromatin alterations. Gene-expression and chromatin accessibility analyses identify distinct mechanisms as well as markers predictive of metastatic progression in both groups. Underlying the difference between the two programs was the cell type of origin of the tumors, with NFIB-independent metastases arising from mature neuroendocrine cells. Our findings underscore the importance of the identity of cell type of origin in influencing tumor evolution and metastatic mechanisms. We show that SCLC can arise from different cell types of origin, which profoundly influences the eventual genetic and epigenetic changes that enable metastatic progression. Understanding intertumoral heterogeneity in SCLC, and across cancer types, may illuminate mechanisms of tumor progression and uncover how the cell type of origin affects tumor evolution. .

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-17-0987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195211PMC
October 2018
23 Reads
15.930 Impact Factor

Publication Analysis

Top Keywords

cell type
20
type origin
20
tumor evolution
12
early events
8
model tumors
8
metastatic progression
8
chromatin accessibility
8
heterogeneity sclc
8
intertumoral heterogeneity
8
cell
7
metastatic
6
origin
6
type
5
markers predictive
4
predictive metastatic
4
distinct mechanisms
4
progression groups
4
mechanisms well
4
well markers
4
underlying difference
4

Similar Publications