The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry.

Future Oncol 2018 11 12;14(26):2713-2723. Epub 2018 Sep 12.

Immunology & Allergology, University of Salerno, Salerno, Italy.

Aim: We collected 'real-life' data on the management of patients with mastocytosis in the Italian Mastocytosis Registry.

Methods: Six hundred patients diagnosed with mastocytosis between 1974 and 2014 were included from 19 centers.

Results: Among adults (n = 401); 156 (38.9%) patients were diagnosed with systemic mastocytosis. In 212 adults, no bone marrow studies were performed resulting in a provisional diagnosis of mastocytosis of the skin. This diagnosis was most frequently established in nonhematologic centers. In total, 182/184 pediatric patients had cutaneous mastocytosis. We confirmed that in the most patients with systemic mastocytosis, serum tryptase levels were >20 ng/ml and KIT D816V was detectable.

Conclusion: The Italian Mastocytosis Registry revealed some center-specific approaches for diagnosis and therapy. Epidemiological evidence on this condition is provided.

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http://dx.doi.org/10.2217/fon-2018-0291DOI Listing
November 2018
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References

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Valent P et al.
Hematology Am. Soc. Hematol. Educ. Program 2015

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