Metabolic effects of reduced growth hormone action in fatty liver disease.

Hepatol Int 2018 Sep 11;12(5):474-481. Epub 2018 Sep 11.

Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Background: Adult growth hormone (GH) deficiency is associated with fatty liver disease and shows several features of the metabolic syndrome. Vice versa obesity is characterized as a state of low GH function. Here, we aimed to define the role of hepatic GH signaling and its metabolic consequences in non-alcoholic fatty liver disease.

Methods: In humans, GHR and IGF-1 levels were determined in liver samples of 29 obese patients with non-alcoholic steatohepatitis (NASH) or simple steatosis. Cellular effects of GH on insulin signaling were investigated in GH receptor (GHR) knockdown HepG2 cells.

Results: Hepatic IGF-1 expression levels reflecting GH action were significantly lower and fasting glucose concentrations higher in patients with NASH than in patients with simple steatosis. GHR knockdown in hepatocytes resulted in a scenario of high glucose output displayed by reduced glycogen content, increased gluconeogenesis and diminished insulin signaling.

Conclusions: Our data suggest that GH signaling in the liver is diminished in patients with NASH and associated with deteriorated hepatic insulin sensitivity and metabolic activity. Reduced hepatic GH action might contribute to insulin resistance in obese patients with NASH.

Download full-text PDF

Source
http://link.springer.com/10.1007/s12072-018-9893-7
Publisher Site
http://dx.doi.org/10.1007/s12072-018-9893-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208861PMC
September 2018
40 Reads

Publication Analysis

Top Keywords

fatty liver
12
patients nash
12
simple steatosis
8
liver disease
8
growth hormone
8
obese patients
8
ghr knockdown
8
liver
5
patients
5
cellular effects
4
metabolic
4
signaling liver
4
steatosis cellular
4
receptor ghr
4
investigated receptor
4
insulin signaling
4
signaling investigated
4
signalingconclusions data
4
effects insulin
4
data signaling
4

Similar Publications