Topical Selenium Sulfide for the Treatment of Hyperkeratosis.

Authors:
Philip R Cohen
Philip R Cohen
University of Houston
United States
Caesar A Anderson
Caesar A Anderson
Centers for Wound Healing and Hyperbaric Medicine
Longview | United States

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):639-646. Epub 2018 Sep 10.

University of California San Diego Hyperbaric Medicine and Wound Healing Center, Encinitas, CA, USA.

Hyperkeratosis presents as thickened skin. It can be congenital or acquired. Typically, it affects the palms and soles; the distribution of epidermal involvement is either diffuse, focal, or punctate. Microscopically, the pathologic signature of hyperkeratosis is marked orthokeratosis of the stratum corneum. Topical treatments provide the mainstay of therapy for hyperkeratosis. These include keratolytics (such as urea, salicylic acid, and lactic acid) and retinoids; physical debridement, topical corticosteroids, and phototherapy (using topical psoralen and ultraviolet A phototherapy) are other local therapeutic modalities. Selenium is a non-metallic essential element; its water-insoluble salt, selenium sulfide, is an active ingredient that is used (in either a foam, lotion, or shampoo) to treat not only seborrheic dermatitis but also tinea versicolor. Three individuals with hyperkeratosis involving their palms and/or soles are described; the hyperkeratosis was successful treated with topical selenium sulfide in either a 2.5% lotion/shampoo or a 2.75% foam. The response to topical selenium sulfide was not only rapid but also complete and sustained; none of the patients experienced any adverse events secondary to the therapy. In conclusion, we recommend that topical selenium sulfide be added to the therapeutic armamentarium for congenital or acquired hyperkeratosis-particularly for those patients with involvement of their palms and soles.

Download full-text PDF

Source
http://link.springer.com/10.1007/s13555-018-0259-9
Publisher Site
http://dx.doi.org/10.1007/s13555-018-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261123PMC
December 2018
12 Reads

Article Mentions


Provided by Crossref Event Data
twitter
Twitter: DermatolTher
September 29, 2018, 7:30 am EST

Publication Analysis

Top Keywords

selenium sulfide
20
topical selenium
16
palms soles
8
congenital acquired
8
topical
7
hyperkeratosis
6
selenium
5
sulfide
5
water-insoluble salt
4
ingredient foam
4
salt selenium
4
sulfide active
4
active ingredient
4
foam lotion
4
treat seborrheic
4
versicolor three
4
three individuals
4
individuals hyperkeratosis
4
tinea versicolor
4
dermatitis tinea
4

References

(Supplied by CrossRef)
Article in Am J Clin Dermatol
S Patel et al.
Am J Clin Dermatol 2007
Article in Int J Dermatol
JF Okulicz et al.
Int J Dermatol 2003
Article in J Am Acad Dermatol
N Patel et al.
J Am Acad Dermatol 2006
Article in J Toxicol Clin Toxicol
DG Barceloux et al.
J Toxicol Clin Toxicol 1999
Article in Biomed Environ Sci
G-I Xu et al.
Biomed Environ Sci 1997
Article in Scand J Rheumatol
E Allander et al.
Scand J Rheumatol 1994
Article in Br Med J
DA Ruta et al.
Br Med J 1989
Article in Chest
A Schecter et al.
Chest 1980
Article in Arch Environ Health
LC Alderman et al.
Arch Environ Health 1986
Article in J Toxicol Clin Toxicol
CG Wilber et al.
J Toxicol Clin Toxicol 1980

Similar Publications