The Genetic Basis of Adaptation following Plastic Changes in Coloration in a Novel Environment.

Authors:
Ammon Corl
Ammon Corl
University of California
United States
Ke Bi
Ke Bi
University of Guelph
Canada
Akshara Sree Challa
Akshara Sree Challa
University of California
Barry Sinervo
Barry Sinervo
University of California
Tempe | United States
Rasmus Nielsen
Rasmus Nielsen
University of California
United States

Curr Biol 2018 Sep 6;28(18):2970-2977.e7. Epub 2018 Sep 6.

Department of Integrative Biology, University of California, Berkeley, 3040 Valley Life Sciences Building # 3140, Berkeley, CA 94720-3140, USA.

Phenotypic plasticity has been hypothesized to precede and facilitate adaptation to novel environments [1-8], but examples of plasticity preceding adaptation in wild populations are rare (but see [9, 10]). We studied a population of side-blotched lizards, Uta stansburiana, living on a lava flow that formed 22,500 years ago [11] to understand the origin of their novel melanic phenotype that makes them cryptic on the black lava. We found that lizards living on and off of the lava flow exhibited phenotypic plasticity in coloration but also appeared to have heritable differences in pigmentation. We sequenced the exomes of 104 individuals and identified two known regulators of melanin production, PREP and PRKAR1A, which had markedly increased levels of divergence between lizards living on and off the lava flow. The derived variants in PREP and PRKAR1A were only found in the lava population and were associated with increased pigmentation levels in an experimental cohort of hatchling lizards. Simulations suggest that the derived variants in the PREP and PRKAR1A genes arose recently and were under strong positive selection in the lava population. Overall, our results suggest that ancestral plasticity for coloration facilitated initial survival in the lava environment and was followed by genetic changes that modified the phenotype in the direction of the induced plastic response, possibly through de novo mutations. These observations provide a detailed example supporting the hypothesis that plasticity aids in the initial colonization of a novel habitat, with natural selection subsequently refining the phenotype with genetic adaptations to the new environment. VIDEO ABSTRACT.

Abstract Video

Plasticity and Adaptation in a Novel Environment/ Curr. Biol., Sep. 6, 2018 (Vol. 28, Issue 18)


Source: Cell Press

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September 2018
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