Lymphocyte populations and their change during five-year glatiramer acetate treatment.

Neurol Neurochir Pol 2018 Sep - Oct;52(5):587-592. Epub 2018 Aug 18.

Department of Neurology, Faculty of Medicine and University Hospital Hradec Králové, Charles University in Prague, Hradec Králové, Sokolská 581, 500 05, Czech Republic.

Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA).

Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org).

Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment.

Conclusion: This study presents some parameters that were affected by long-term GA treatment.

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http://dx.doi.org/10.1016/j.pjnns.2018.08.001DOI Listing
June 2019
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