From formulation of acrylamide-based hydrogels to their optimization for drug release using response surface methodology.

Mater Sci Eng C Mater Biol Appl 2018 Nov 18;92:20-25. Epub 2018 Jun 18.

Department of Clinical Pharmacy, Faculty of Pharmacy, M. Clinical Pharmacy, National University of Malaysia (UKM), 43600 UKM Bangi, Selangor, Malaysia.

This study conducted on the structure of modified acrylamide-based hydrogel by synthesizing the nano composites. The hydrogels employed in this study were provided through a combination of acrylamide monomers, sodium carboxymethyl cellulose (NaCMC) and magnesium oxide (MgO) nanoparticles by crosslinking polymerization. N,N,N',N'-tetramethylethylenediamine and ammonium persulfate as the initiator was applied in the structure of the polymer. Findings of the study considered the nano composites consisting of MgO have the highest swelling ratio compared to pure Aam hydrogels. Thus, MgO is an appropriate nanoparticle to be used in the nano composites. Response surface methodology (RSM) based on a central composite design (CCD Design) was applied to optimize the preparation variables of a hydrogel consisted of MgO, NaCMC. With the swelling ratio for acrylamide-based hydrogel as the response, the effects of two variables, i.e. MgO and NaCMC were investigated. The effects of pH, temperature, MgO, and NaCMC on the drug release were investigated using the CCD design. The predicted appropriate drug release conditions for the hydrogel at the highest rate of temperature (37.50 °C) and pH: 4.10, is at its highest value, while the lower drug release is at temperature 38 °C and pH 3.50. With the desired value of MgO (0.01 g) and amount of NaCMC (0.1 g).

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Source
https://linkinghub.elsevier.com/retrieve/pii/S09284931173407
Publisher Site
http://dx.doi.org/10.1016/j.msec.2018.06.022DOI Listing
November 2018

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