Salivary opiorphin levels in anorexia nervosa: a case control study.

World J Biol Psychiatry 2018 Sep 4:1-18. Epub 2018 Sep 4.

e Department of Child and Adolescent Psychiatry , PUMS , Poznań , Poland.

Objectives: Opiorphin is a physiological inhibitor of peptidases inactivating endogenous opioids displaying strong analgesic properties without undesirable side effects, antidepressant properties and hormonal dependency. It might therefore play an important role in patients with painful diseases related to neuro-hormonal dysregulation of the nervous system, affecting saliva secretion and composition such as anorexia (AN). The main objective aim of this study was to compare the level of opiorphin in saliva of patients with AN to matched subjects free of eating disorders.

Methods: A case control clinical trial was conducted in 68 AN patients and 43 healthy matched control subjects. Depression symptoms were assessed with the self-scored questionnaire Beck Depression Inventory (BDI) and salivary samples were taken during the acute stage of AN (BMI < 15kg/m) for measuring opiorphin. Opiorphin levels were measured with a quantitative assay using commercial immunoenzymatic Elisa kit (cat no. EH1927, Wuchan, Hubei, China).

Results: No statistically significant difference was found in salivary opiorphin levels between the AN and control groups, (p = 0.499, Mann-Whitney U test). Positive correlations to duration of the disease, BDI and bodyweight in AN patients were evidenced.

Conclusions: Measurement of salivary opiorphin levels cannot be used as a marker of AN but may allow new perspectives in monitoring AN in its early stages.

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http://dx.doi.org/10.1080/15622975.2018.1517948DOI Listing
September 2018
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