Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition.

Int J Cancer 2019 04 21;144(7):1511-1521. Epub 2018 Dec 21.

International Agency for Research on Cancer, Lyon, France.

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; p = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, p = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p = 0.99). We found no association between dietary folate intake and PC risk in this large European study.

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ijc.31830
Publisher Site
http://dx.doi.org/10.1002/ijc.31830DOI Listing
April 2019
53 Reads

Publication Analysis

Top Keywords

folate intake
20
pancreatic cancer
8
intake risk
8
dietary folate
8
intake
7
folate
6
risk
6
bmi educational
4
865 incident
4
incident primary
4
years 865
4
participants years
4
cases recorded
4
intake energy-adjusted
4
status bmi
4
recorded folate
4
educational level
4
primary cases
4
level diabetes
4
status supplement
4

References

(Supplied by CrossRef)

Ferlay J et al.
2013

World Cancer Research Fund/American Institute for Cancer Research et al.
2012
Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal Cancer?
Kim YI et al.
Cancer Epidemiol Biomarkers Prev 2004

Similar Publications