[Drug-induced vasculitis].

Authors:
Neila Fathallah
Neila Fathallah
Farhat Hached Hospital
Sana Mokni
Sana Mokni
Fattouma Bourguiba Hospital
Khadija Baccouche
Khadija Baccouche
Saint-Antoine Hospital
Amira Atig
Amira Atig
Service de Médecine Interne
Angers | France
Najat Ghariani
Najat Ghariani
Département de dermatologie
Mohamed Denguezli
Mohamed Denguezli
Farhat Hached Hospital

Therapie 2018 Jul 24. Epub 2018 Jul 24.

Département de pharmacologie, faculté de médecine de Sousse, université de Sousse, avenue Md Karoui, 4002 Sousse, Tunisie.

Introduction: Drug-induced vasculitis is reported in almost 10-20 % of vasculitis. Several drugs may be incriminated in their occurrence. Our study aimed to study the epidemiological, clinical, histopathological and evolutionary characteristics of drug-indced vasculitis from a series of cases and to specify the different drugs involved.

Methods: We conducted a retrospective study during the period from January 2006 to December 2015 from the cases notified to the regional pharmacovigilance center of Sousse, Tunisia. The diagnosis was established according to the criteria proposed by the group of the American college of rheumatology (ACR).

Results: Our study included thirteen cases of drug-induced vasculitis over a ten-year period, with an mean incidence of 1.3 new cases per year. Mean age of patients was 40.84 years. The mean delay from the treatment onset was 14.46 days with extremes ranging from 5 days to six weeks. Most patients had pure skin involvement. Association with other extracutaneous complaints was present in five cases. Cutaneous biopsy was performed in all patients showing a pathological pattern of leukocytoclastic vasculitis, associated with fibrinoid necrosis, extravasation of red blood cells and allergic capillaritis. The outcome was favorable for all patients. The offending drugs in our series were amoxicillin, pristinamycin, rifampicin, fluconazole, metformin, glimepiride, phenobarbital, gabapentin, fenofibrate, ibuprofen, allopurinol, rituximab and tinzaparin.

Conclusion: Anamnestic, clinical, biological and histopathological findings allow the early recognition of drug-induced vasculitis. Adequate treatment prevents systemic spreading and a worse prognosis.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.therap.2018.07.005DOI Listing
July 2018
49 Reads

Publication Analysis

Top Keywords

drug-induced vasculitis
12
vasculitis
6
cases
5
involvement association
4
association extracutaneous
4
extracutaneous complaints
4
complaints cases
4
days weeks
4
patients pure
4
pure skin
4
skin involvement
4
cases cutaneous
4
weeks patients
4
biopsy performed
4
pattern leukocytoclastic
4
leukocytoclastic vasculitis
4
vasculitis associated
4
pathological pattern
4
showing pathological
4
ranging days
4

Similar Publications