Antitumor activity of extract and isolated compounds from and .

Authors:
Dr. Mehnaz Kamal, PhD
Dr. Mehnaz Kamal, PhD
College of Pharmacy, Prince Sattam Bin Abdulaziz University
Assistant Professor
Medicinal chemistry
Al Kharj, Riyadh | Saudi Arabia

Saudi Pharm J 2018 Feb 27;26(2):279-285. Epub 2017 Nov 27.

Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.

Total extracts of and in addition of two isolated compounds from their cultures [-2-ethylhexyl phthalate () and 1,8-Dihydroxy-3-methoxy-6-methyl-anthraquinone ()] were tested for their antitumor activity using four human carcinoma cell lines. Antitumor activity was assessed by performing MTT assay to check the % cell viability. The % viability of HCT-116 (colon carcinoma), HeLa (cervical carcinoma), HEp-2 (larynx carcinoma) and HepG-2 (hepatocellular carcinoma) cells decreased after treatment with and extracts, these effects were ranged from 059.0 ±  0.1 to 217.0  ±  0.3 µg/ml on all types of cancer cells. The best activity was recorded for extract (054.5 ± 0.3, 059.0 ± 0.5 and 059.0 ± 0.1 for HEp-2, Hela, and HepG-2 respectively). The isolated compounds (&) were found to be responsible about the activities because they recorded the lowest IC on tested cell lines with range of 9.5-20.3 μg/ml. Vinblastine sulphate was used as a reference standard and showed anticancer activity. This study demonstrated that all extracts and isolated compounds have antitumor activity against HCT-116, HeLa, HEp-2 and HepG-2 cells.

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Source
http://dx.doi.org/10.1016/j.jsps.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111196PMC
February 2018
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