Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?

Transl Psychiatry 2018 Aug 30;8(1):169. Epub 2018 Aug 30.

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the "missing heritability" between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that general IQ (gIQ) is associated with (1) polygenic scores for intelligence, (2) epigenetic modification of DRD2 gene, (3) gray matter density in striatum, and (4) functional striatal activation elicited by temporarily surprising reward-predicting cues. Comparing the relative importance for the prediction of gIQ in an overlapping subsample, our results demonstrate neurobiological correlates of the malleability of gIQ and point to equal importance of genetic variance, epigenetic modification of DRD2 receptor gene, as well as functional striatal activation, known to influence dopamine neurotransmission. Peripheral epigenetic markers are in need of confirmation in the central nervous system and should be tested in longitudinal settings specifically assessing individual and environmental factors that modify epigenetic structure.

Download full-text PDF

Source
http://www.nature.com/articles/s41398-018-0222-7
Publisher Site
http://dx.doi.org/10.1038/s41398-018-0222-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117339PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
August 2018
50 Reads

Article Mentions


Provided by Crossref Event Data
twitter
Twitter: CosmicMak
December 18, 2018, 12:21 pm EST
twitter
Twitter: CupPuta
October 7, 2018, 4:43 am EST
twitter
Twitter: CupPuta
October 7, 2018, 3:42 am EST
twitter
Twitter: CupPuta
October 7, 2018, 3:41 am EST
twitter
Twitter: Cuckoobirdd
October 6, 2018, 5:34 am EST
twitter
Twitter: GilbertDeray
October 6, 2018, 4:11 am EST
twitter
Twitter: Tufan_tekeli
October 6, 2018, 2:36 am EST
twitter
Twitter: BerkerErkol
October 5, 2018, 1:38 pm EST
twitter
Twitter: BuketTuran
October 5, 2018, 10:05 am EST
twitter
Twitter: Sehmusenzeli
October 5, 2018, 6:24 am EST
twitter
Twitter: Kizikboyu
October 5, 2018, 5:58 am EST
twitter
Twitter: SeminYaKayhan
October 5, 2018, 5:48 am EST
twitter
Twitter: Muhammedmihci
October 5, 2018, 5:14 am EST
twitter
Twitter: Bilim_man
October 5, 2018, 5:12 am EST
twitter
Twitter: GT_AAM_64
October 4, 2018, 6:19 pm EST
twitter
Twitter: Labome
October 4, 2018, 11:02 am EST
twitter
Twitter: PIONICeer
October 3, 2018, 7:52 am EST
twitter
Twitter: Rejjjuiii
October 3, 2018, 5:47 am EST
twitter
Twitter: GrunauChristoph
September 30, 2018, 3:11 am EST
twitter
Twitter: EvolutaMente
September 28, 2018, 2:19 am EST
twitter
Twitter: Davidprezprez1
September 25, 2018, 5:25 pm EST
twitter
Twitter: Bitacorabeagle
September 25, 2018, 4:17 pm EST
twitter
Twitter: Bitacorabeagle
September 25, 2018, 10:16 am EST
twitter
Twitter: ValerioRizzo_
September 25, 2018, 5:04 am EST
twitter
Twitter: NDonamayor
September 15, 2018, 3:14 am EST
twitter
Twitter: JakobKaminski
September 14, 2018, 6:34 am EST
twitter
Twitter: ChariteBerlin
September 14, 2018, 6:27 am EST
twitter
Twitter: Leafs_s
September 5, 2018, 3:36 am EST
twitter
Twitter: Indrit_sinanaj
September 4, 2018, 3:05 pm EST
twitter
Twitter: Neuromeditate
September 4, 2018, 1:14 pm EST
twitter
Twitter: Roisin_White__
September 4, 2018, 11:55 am EST
twitter
Twitter: Uranus_2
September 4, 2018, 11:16 am EST
twitter
Twitter: Ldeserno
August 31, 2018, 7:34 am EST
twitter
Twitter: JakobKaminski
August 30, 2018, 9:40 am EST

Publication Analysis

Top Keywords

environmental factors
12
test performance
8
cognitive test
8
striatal activation
8
modification drd2
8
factors modify
8
epigenetic modification
8
functional striatal
8
explained genetic
8
epigenetic
7
imagen sample
4
sample general
4
general giq
4
giq associated
4
genetics imagen
4
healthy adolescents
4
adolescents imaging
4
imaging genetics
4
associated polygenic
4
polygenic scores
4

References

(Supplied by CrossRef)
Article in Mol. Psychiatry
G Davies et al.
Mol. Psychiatry 2015
Article in Science
TJ Bouchard et al.
Science 1990
Article in Nat. Genet
TJC Polderman et al.
Nat. Genet 2015
Article in Nat. Genet
S Sniekers et al.
Nat. Genet 2017
Article in Psychol. Bull.
JR Flynn et al.
Psychol. Bull. 1984
Article in Psychol. Bull.
JR Flynn et al.
Psychol. Bull. 1987
Article in Mol. Psychiatry
S Karama et al.
Mol. Psychiatry 2014
Article in Hum. Brain Mapp.
M Burgaleta et al.
Hum. Brain Mapp. 2014
Article in Brain Imaging Behav.
PA MacDonald et al.
Brain Imaging Behav. 2014
Article in Hum. Brain Mapp.
RG Grazioplene et al.
Hum. Brain Mapp. 2015
Article in J. Neurosci.
AP Mackey et al.
J. Neurosci. 2013

Similar Publications