An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.

Authors:
Yee Lian Chew
Yee Lian Chew
University of Sydney
Australia
Yoshinori Tanizawa
Yoshinori Tanizawa
Nagoya University
Japan
Yongmin Cho
Yongmin Cho
Korea University
Buyun Zhao
Buyun Zhao
MRC Laboratory of Molecular Biology
Alex J Yu
Alex J Yu
University of British Columbia
Evan L Ardiel
Evan L Ardiel
University of British Columbia
Canada
Ithai Rabinowitch, PhD
Ithai Rabinowitch, PhD
Hebrew University of Jerusalem
Senior Lecturer
Neuroscience
Jerusalem | Israel
Jihong Bai
Jihong Bai
University of Wisconsin
United States

Neuron 2018 Sep 23;99(6):1233-1246.e6. Epub 2018 Aug 23.

Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, Cambridgeshire, CB2 0QH, UK. Electronic address:

Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal sensitization is an important feature of arousal in many organisms, yet its molecular and neural mechanisms are incompletely understood. Here we show that in C. elegans, aversive mechanical stimuli lead to both enhanced locomotor activity and sensitization of aversive chemosensory pathways. Both locomotor arousal and cross-modal sensitization depend on the release of FLP-20 neuropeptides from primary mechanosensory neurons and on their receptor FRPR-3. Surprisingly, the critical site of action of FRPR-3 for both sensory and locomotor arousal is RID, a single neuroendocrine cell specialized for the release of neuropeptides that responds to mechanical stimuli in a FLP-20-dependent manner. Thus, FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states.

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Neuropeptides Modulate Behavioral Arousal in Worms


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http://dx.doi.org/10.1016/j.neuron.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162336PMC

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September 2018
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