Coxsackievirus B5 Aseptic Meningitis in Infants in Chiba Prefecture, Japan, in 2016.

Authors:
Kanae Tsuno
Kanae Tsuno
Nippon Medical School Chiba Hokusoh Hospital
Chiharu Miyatake
Chiharu Miyatake
Nippon Medical School Chiba Hokusoh Hospital
Tomoko Ogawa
Tomoko Ogawa
Graduate School of Medicine
Japan
Takeshi Asano
Takeshi Asano
Nippon Medical School
Japan

J Nippon Med Sch 2018 ;85(3):187-190

Department of Pediatrics, Nippon Medical School Chiba Hokusoh Hospital.

Background: Infantile aseptic meningitis is a rare infection of the central nervous system. Coxsackievirus B5 (CVB5) is an enterovirus that is sometimes associated with aseptic meningitis and encephalitis.

Case Presentation: We report on three isolated infants with aseptic meningitis caused by CVB5 in the spring and summer of 2016 with nearly identical 404-bp CVB5 Viral Capsid Protein 1 (VP1) sequences. In addition, viral analysis of sewage samples from Chiba Prefecture in 2016 showed similar 404-bp CVB5 VP1 sequences from May to September 2016.

Conclusion: These results indicate that viral screening of sewage water may help detect occult outbreaks of viral infection, particularly for enterovirus strains.

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Source
http://dx.doi.org/10.1272/jnms.JNMS.2018_85-28DOI Listing
October 2018
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