Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.

Annu Rev Pharmacol Toxicol 2019 Jan 22;59:463-486. Epub 2018 Aug 22.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA; email:

Adverse drug reactions (ADRs) are a significant health care burden. Immune-mediated adverse drug reactions (IM-ADRs) are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity. Variation in human leukocyte antigen ( HLA) genes has emerged as a potential preprescription screening strategy for the prevention of previously unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of immunogenomics and pharmacogenomics and focuses on the effects of immune-specific variation on drug disposition and IM-ADRs. In this review, we present the latest evidence for HLA associations with IM-ADRs, ongoing research into biological mechanisms of IM-ADRs, and the translation of clinical actionable biomarkers for IM-ADRs, with a focus on T cell-mediated ADRs.

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Source
https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-0
Publisher Site
http://dx.doi.org/10.1146/annurev-pharmtox-010818-021818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409210PMC
January 2019
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