Cell Biol Int 2013 Jul 18;37(7):731-6. Epub 2013 Apr 18.
Center for Medical Science, International University of Health and Welfare, Kitakanamaru, Otawara, Tochigi, Japan.
RA175/SynCAM1/Cadm1 (Cadm1), a member of the immunoglobulin superfamily, is a synaptic cell adhesion molecule that has a PDZ-binding motif at the C-terminal region. It promotes the formation of presynaptic terminals and induces functional synapses in the central nervous system. Cadm1-deficient (knockout [KO]) mice show behavioral abnormalities, including excessive aggression and anxiety, but do not show any symptoms of neuromuscular disorder, although neuromuscular junctions (NMJs) have structures similar to synapses. Read More