Functional gradients of the cerebellum.

Elife 2018 08 14;7. Epub 2018 Aug 14.

McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, United States.

A central principle for understanding the cerebral cortex is that macroscale anatomy reflects a functional hierarchy from primary to transmodal processing. In contrast, the central axis of motor and nonmotor macroscale organization in the cerebellum remains unknown. Here we applied diffusion map embedding to resting-state data from the Human Connectome Project dataset (n = 1003), and show for the first time that cerebellar functional regions follow a gradual organization which progresses from primary (motor) to transmodal (DMN, task-unfocused) regions. A secondary axis extends from task-unfocused to task-focused processing. Further, these two principal gradients revealed novel functional properties of the well-established cerebellar double motor representation (lobules I-VI and VIII), and its relationship with the recently described triple nonmotor representation (lobules VI/Crus I, Crus II/VIIB, IX/X). Functional differences exist not only between the two motor but also between the three nonmotor representations, and second motor representation might share functional similarities with third nonmotor representation.

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http://dx.doi.org/10.7554/eLife.36652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092123PMC
August 2018
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References

(Supplied by CrossRef)
Cerebellar neurocognition: insights into the bottom of the brain
Baillieux et al.
Clinical Neurology and Neurosurgery 2008
Vestibular involvement in cognition: visuospatial ability, attention, executive function, and memory
Bigelow et al.
Journal of Vestibular Research : Equilibrium & Orientation 2015
The brain's default network: anatomy, function, and relevance to disease
Buckner et al.
Annals of the New York Academy of Sciences 2008

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