Telomere Length as Cardiovascular Aging Biomarker: JACC Review Topic of the Week.

J Am Coll Cardiol 2018 08;72(7):805-813

Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain; CIBER de Enfermedades Cardiovasculares (CIBER-CV), Madrid, Spain.

Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease (aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical telomere shortening may contribute to premature biological aging and aCVD. Therefore, telomere length often is suggested as a causal aCVD risk factor, a proposal supported by recent Mendelian randomization studies; however, epidemiological research has shown disappointingly low effect sizes. It therefore remains uncertain whether telomere shortening is a cause of aCVD or merely a consequence. The authors argue that elucidating the mechanistic foundation of these findings is essential for any possible translation of telomere biology to the clinic. Here, they critically evaluate evidence for causality in animal models and human studies, and review popular hypotheses and discuss their clinical implications. The authors identify 4 key questions that any successful mechanistic theory should address, and they discuss how atherosclerosis-associated local telomere attrition may provide the answers.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2018.06.014DOI Listing
August 2018

Publication Analysis

Top Keywords

risk factor
8
telomere shortening
8
telomere length
8
telomere
6
acvd
5
mechanistic foundation
4
elucidating mechanistic
4
authors argue
4
consequence authors
4
argue elucidating
4
foundation findings
4
telomere biology
4
biology clinic
4
translation telomere
4
essential translation
4
findings essential
4
acvd consequence
4
shortening acvd
4
mendelian randomization
4
randomization studies
4

Similar Publications