Regulatory T cells in paracoccidioidomycosis.

Authors:
Ronei L Mamoni
Ronei L Mamoni
University of Campinas
Brazil

Virulence 2018 Aug 1:1-12. Epub 2018 Aug 1.

a Department of Immunology , Institute of Biomedical Sciences, University of São Paulo (USP) , São Paulo , Brazil.

This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen. A brief introduction on the general features of Treg cells summarizes their main functions, subpopulations, mechanisms of suppression and plasticity. The main aspects of immunity in the diverse forms of the P. brasiliensis infection are presented, as are the few extant studies on the relevance of Treg cells in the control of severity of the human disease. Finally, the influence of Toll-like receptors, Dectin-1, NOD-like receptor P3 (NLRP3), Myeloid differentiation factor-88 (MyD88), as well as the enzyme indoleamine 2,3 dioxygenase (IDO) on the expansion and function of Treg cells in a murine model of pulmonary paracoccidioidomycosis (PCM) is also discussed. It is demonstrated that some of these components are involved in the negative control of Treg cell expansion, whereas others positively trigger the proliferation and activity of these cells. Finally, the studies here summarized highlight the dual role of Treg cells in PCM, which can be protective by controlling excessive immunity and tissue pathology but also deleterious by inhibiting the anti-fungal immunity necessary to control fungal growth and dissemination.

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21505594.2018.1
Publisher Site
http://dx.doi.org/10.1080/21505594.2018.1483674DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
August 2018
31 Reads

Publication Analysis

Top Keywords

treg cells
16
regulatory cells
8
cells
6
treg
5
control severity
4
human disease
4
severity human
4
summarized highlight
4
disease finally
4
finally influence
4
receptors dectin-1
4
cells finally
4
dectin-1 nod-like
4
finally studies
4
toll-like receptors
4
cells control
4
influence toll-like
4
studies summarized
4
studies relevance
4
demonstrated components
4

Similar Publications