A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.

Authors:
Juliana Menegussi
Juliana Menegussi
Universidade Federal do Espírito Santo
Weverton Machado Luchi
Weverton Machado Luchi
Universidade Federal do Espirito Santo

J Bras Nefrol 2018 Oct-Dec;40(4):410-417. Epub 2018 Jul 23.

Universidade Federal do Espírito Santo, Departamento de Clínica Médica, Divisão de Nefrologia, Vitória, ES, Brasil.

Hyperkalemic renal tubular acidosis is a non-anion gap metabolic acidosis that invariably indicates an abnormality in potassium, ammonium, and hydrogen ion secretion. In clinical practice, it is usually attributed to real or apparent hypoaldosteronism caused by diseases or drug toxicity. We describe a 54-year-old liver transplant patient that was admitted with flaccid muscle weakness associated with plasma potassium level of 9.25 mEq/L. Additional investigation revealed type 4 renal tubular acidosis and marked hypomagnesemia with high fractional excretion of magnesium. Relevant past medical history included a recent diagnosis of Paracoccidioidomycosis, a systemic fungal infection that is endemic in some parts of South America, and his outpatient medications contained trimethoprim-sulfamethoxazole, tacrolimus, and propranolol. In the present acid-base and electrolyte case study, we discuss a clinical approach for the diagnosis of hyperkalemic renal tubular acidosis and review the pathophysiology of this disorder.

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Source
http://dx.doi.org/10.1590/2175-8239-JBN-3821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534002PMC

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July 2018
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