Urine miRNA as a potential biomarker for bladder cancer detection - a meta-analysis.

Cent European J Urol 2018 28;71(2):177-185. Epub 2018 Mar 28.

Medical University of Łódź, 1 Department of Urology, Łódź, Poland.

Introduction: White light cystoscopy (WLC), often supported by urine cytology, is considered the 'goldstandard' in the diagnosis and follow-up of bladder cancer (BCa). In recent years, urine microRNA (miRNA) tests have been performed for the detection of bladder cancer.

Material And Methods: A systematic review of the PubMed platform was performed by searching for articles in which miRNA in the urine was used for the detection of BCa.

Results: The greatest sensitivity (86.6%) in BCa detection was achieved for multi-miRNA in urine sediment. The greatest specificity (85.3%) was achieved for multi-miRNA from voided urine. There were significant differences (p <0.01) between single-miRNA (OR 8.96; CI 6.37-12.59) and the multi-miRNA group (OR 19.95; CI 13.35-29.81). There were no differences among the specimens (voided urine, supernatant, sediment) used for the test.

Conclusions: Urine miRNAs have the potential to be a valid marker for bladder cancer detection. They can successfully compete with other non-invasive diagnostic tests.

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Source
http://dx.doi.org/10.5173/ceju.2018.1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051360PMC
March 2018

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