The efficacy of dextrose prolotherapy over placebo for temporomandibular joint hypermobility: A systematic review and meta-analysis.

Authors:
Shakil Ahmed Nagori
Shakil Ahmed Nagori
All India Institute of Medical Sciences
India
Dr Anson Jose, MDS
Dr Anson Jose, MDS
All India Institute of Medical Sciences
Oral and maxillofacial surgeon
Oral and maxillofacial surgery
New delhi, new delhi | India
Venkatesan Gopalakrishnan
Venkatesan Gopalakrishnan
Military Dental Centre (Kirkee)
Indranil Deb Roy
Indranil Deb Roy
Army Hospital (R&R)
India
Probodh K Chattopadhyay
Probodh K Chattopadhyay
Professor and Department Head
Ajoy Roychoudhury
Ajoy Roychoudhury
All India Institute of Medical Sciences
India

J Oral Rehabil 2018 Dec 3;45(12):998-1006. Epub 2018 Aug 3.

Department of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, New Delhi, India.

Objective: The aim of the systematic review was to analyse the available evidence in order to assess the efficacy of dextrose prolotherapy in improving outcomes in temporomandibular joint (TMJ) hypermobility patients as compared to placebo.

Methods: An electronic search of PubMed, Scopus, CENTRAL and Google scholar databases was performed for English language papers published up to February 2018. Randomised clinical trials (RCTs) and controlled clinical trials (CCTs) comparing dextrose prolotherapy with placebo for TMJ hypermobility were included.

Results: Three RCTs were included in the review. Frequency of subluxation/dislocation was reported by two trials which found no difference between dextrose and placebo. A statistical significant difference in reduction of MMO with the use of dextrose prolotherapy was seen on pooling of data (random: MD = -3.32, 95% CI -5.26 to -1.28; P = 0.0008; I  = 0%). A statistical significant difference in pain reduction was also seen with dextrose as compared to placebo (random: MD = -1, 95% CI -1.58 to -0.42; P = 0.0007; I  = 0%).

Conclusion: Within the limitations of the study, dextrose prolotherapy may cause significant reduction in mouth opening and pain associated with TMJ hypermobility. Conclusions with regard to reduction of episodes of subluxation/dislocation cannot be drawn. There is a need of more high-quality RCTs with larger sample size and homogenous prolotherapy protocol to draw stronger conclusions on the effect of dextrose prolotherapy in patients with TMJ hypermobility.

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Source
http://doi.wiley.com/10.1111/joor.12698
Publisher Site
http://dx.doi.org/10.1111/joor.12698DOI Listing
December 2018
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References

(Supplied by CrossRef)
Temporomandibular joint dislocation
Liddell et al.
Oral Maxillofac Surg Clin North Am 2015

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