Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons.

Authors:
Cristina Mazuski
Cristina Mazuski
University of Cincinnati College of Medicine
United States
John H Abel
John H Abel
University of California at Santa Barbara
Tracey O Hermanstyne
Tracey O Hermanstyne
Washington University School of Medicine
Bani Waled | Libya
Jeff R Jones
Jeff R Jones
University of South Florida
United States
Francis J Doyle
Francis J Doyle
University of California
United States
Erik D Herzog
Erik D Herzog
Washington University
Saint Louis | United States

Neuron 2018 Aug 12;99(3):555-563.e5. Epub 2018 Jul 12.

Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker, integrating environmental input to align physiological and behavioral rhythms to local time cues. Approximately 10% of SCN neurons express vasoactive intestinal polypeptide (VIP); however, it is unknown how firing activity of VIP neurons releases VIP to entrain circadian rhythms. To identify physiologically relevant firing patterns, we optically tagged VIP neurons and characterized spontaneous firing over 3 days. VIP neurons had circadian rhythms in firing rate and exhibited two classes of instantaneous firing activity. We next tested whether physiologically relevant firing affected circadian rhythms through VIP release. We found that VIP neuron stimulation with high, but not low, frequencies shifted gene expression rhythms in vitro through VIP signaling. In vivo, high-frequency VIP neuron activation rapidly entrained circadian locomotor rhythms. Thus, increases in VIP neuronal firing frequency release VIP and entrain molecular and behavioral circadian rhythms. VIDEO ABSTRACT.

Abstract Video

Neurons Tango to Synchronize Their Daily Rhythms


Source: Cell Press

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http://dx.doi.org/10.1016/j.neuron.2018.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085153PMC

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August 2018
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