Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors.

Acta Pharmacol Sin 2019 Jan 12;40(1):9-12. Epub 2018 Jul 12.

Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

Myocardial infarction (MI) is one of the most serious health threats, resulting in huge physical and economic burdens worldwide. Wnt signaling pathways play an important role in developmental processes such as tissue patterning, cell differentiation and cell division. Appropriate regulation of the activities of Wnt signaling pathways is also important for heart development and healing in post-MI heart. Moreover, Wnt pathway inhibitors have been identified as novel antitumor drugs and applied in ongoing clinical trials. This research progress has generated increasing interests for investigating the effects of Wnt pathway inhibitors on MI healing. In this short review, we summarize the roles of Wnt signaling pathways in post-MI heart and the therapeutic effects of Wnt pathway inhibitors on MI, and discuss the underlying mechanisms of Wnt pathway inhibitors in cardiac repairing.

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Source
http://www.nature.com/articles/s41401-018-0060-4
Publisher Site
http://dx.doi.org/10.1038/s41401-018-0060-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318317PMC
January 2019
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