Changes in proton pump inhibitor prescribing trend over the past decade and pharmacists' effect on prescribing practice at a tertiary hospital.

BMC Health Serv Res 2018 07 11;18(1):537. Epub 2018 Jul 11.

Department of Pharmacy, the Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, 646000, China.

Background: Proton pump inhibitors (PPIs) remain one of the world's most frequently prescribed medications and there is a growing number of publications on correct versus incorrect use of PPIs worldwide. The objective of this observational retrospective study was to assess changes in PPI prescribing trends over the past decade and pharmacists' effect on optimizing PPI prescribing practice at a tertiary hospital in China.

Methods: We collected the prescriptions of PPIs in our hospital from January 2007 to December 2016. Then the rate of PPI prescribing, the defined daily doses (DDDs) and expenditures were calculated and plotted to show the change in utilization of and expenditure on PPIs. Reasons behind this change and effect of pharmacists' intervention were evaluated by investigating the rationality of PPI use through sample surveys of patients of pre-intervention (Jul.-Dec. 2015) and post-intervention (Jul.-Dec. 2016).

Results: In outpatient settings, the rate of PPI prescribing remained almost constant, utilization (from 135,808 DDDs to 722,943 DDDs) and expenditure (from 1.85 million CNY to 7.96 million CNY) increased for the past ten years, dominated by oral formulations and rabeprazole. In contrast, in inpatient settings, the rate of PPI prescribing (from 20.41 to 37.21%), utilization (from 132,329 DDDs to 827,747 DDDs) and expenditure (from 3.15 million CNY to 25.29 million CNY) increased from 2007 to 2015 and then decreased, dominated by injection formulations and omeprazole. Pharmacist interventions could significantly promote the rational use of PPIs (44.00% versus 26.67%), decrease PPI use and reduce patients' charges (Pā€‰<ā€‰0.05).

Conclusions: The utilization of and expenditure on PPIs grew due to the increase of patients and irrational use of PPI. Pharmacist interventions help to reduce PPI utilization and expenditure and enhance rationality for inpatients, but much work should be done to regulate injection and originator formulas, and improve the rationality in the future.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12913-018-3358-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042351PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
July 2018
40 Reads

Publication Analysis

Top Keywords

ppi prescribing
20
rate ppi
12
ddds expenditure
8
tertiary hospital
8
decade pharmacists'
8
prescribing practice
8
cny increased
8
settings rate
8
practice tertiary
8
proton pump
8
ppi
7
prescribing
7
ppis
5
ddds
5
jul-dec 2015
4
outpatient settings
4
2015 post-intervention
4
2016results outpatient
4
post-intervention jul-dec
4
jul-dec 2016results
4

References

(Supplied by CrossRef)
Article in CMAJ
P Webster et al.
CMAJ 2017
Article in Postepy Hig Med Dosw (Online)
M Kazberuk et al.
Postepy Hig Med Dosw (Online) 2016
Article in Eklem Hastalik Cerrahisi
OS Atik et al.
Eklem Hastalik Cerrahisi 2017
Article in Am J Gastroenterol
NM Guda et al.
Am J Gastroenterol 2004
Article in PLoS One
SR Rotman et al.
PLoS One 2013
Article in Curr Clin Pharmacol
E Ramirez et al.
Curr Clin Pharmacol 2010
Article in Aliment Pharmacol Ther
F Parente et al.
Aliment Pharmacol Ther 2003
Article in Pharm World Sci
K Grant et al.
Pharm World Sci 2006
Article in Am J Gastroenterol
RJ Nardino et al.
Am J Gastroenterol 2000
Article in BMJ
I Forgacs et al.
BMJ 2008
Article in Curr Opin Gastroenterol
NS Abraham et al.
Curr Opin Gastroenterol 2012

Similar Publications