Polyketides and Alkaloids from the Marine-Derived Fungus F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

Mar Drugs 2018 Jul 6;16(7). Epub 2018 Jul 6.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

In our continuous chemical investigation on the marine-derived fungus F31-1, two new polyketides dichocetides B-C (, ), two new alkaloids dichotomocejs E-F (, ), and three known fumiquinozalines: scequinadoline A (), quinadoline A (), and scequinadoline E () were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A () exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A () possesses the potential for further development as a dengue virus inhibitor.

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Source
http://www.mdpi.com/1660-3397/16/7/229
Publisher Site
http://dx.doi.org/10.3390/md16070229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071211PMC
July 2018
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References

(Supplied by CrossRef)
An industry perspective on dengue drug discovery and development
Hernandez-Morales et al.
Adv. Exp. Med. Biol. 2018

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