Neuropeptide B and Vaspin as New Biomarkers in Anorexia Nervosa.

Biomed Res Int 2018 10;2018:9727509. Epub 2018 Jun 10.

Department of Integrated Dentistry, Faculty of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.

Introduction: The aim of the study was to assess the correlation between the levels of neuropeptide B (NPB), neuropeptide W (NPW), vaspin (VAS), and the total antioxidant status (TAS) in the blood, as well as nutritional status of patients with anorexia nervosa (AN).

Materials And Methods: The study covered a cohort of 76 female teenagers, including 46 females with extreme AN and 30 healthy peers (CONTR) aged 12-17.

Results: AN persons were characterized by higher (in comparison to CONTR) NPB and VAS concentrations and lower values of TAS levels, body weight, and anthropometric values. Positive correlations between NPB and VAS levels were noted in the AN group (R=0.33; p<0.001) as well as between concentrations of NPW and VAS in the same group (R=0.49; p<0.001). Furthermore, positive correlations existed between NPB and NPW concentrations across the whole studied population (AN+CONTR; R=0.75; p<0.000001), AN (R=0.73; p<0.000001) and CONTR (R=0.90; p<0.0005).

Conclusions: In detailed diagnostics of AN it is worth considering testing NPB and VAS levels.

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http://dx.doi.org/10.1155/2018/9727509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015710PMC
January 2019
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