Noradrenaline Modulates Visual Perception and Late Visually Evoked Activity.

Authors:
Hagar Gelbard-Sagiv
Hagar Gelbard-Sagiv
Weizmann Institute of Science
Israel
Efrat Magidov
Efrat Magidov
Sackler School of Medicine and Sagol School of Neuroscience
Haggai Sharon
Haggai Sharon
Wohl Institute for Advanced Imaging
Israel
Talma Hendler
Talma Hendler
Wohl Institute for Advanced Imaging
Israel
Yuval Nir
Yuval Nir
Weizmann Institute of Science
Israel

Curr Biol 2018 Jul 5;28(14):2239-2249.e6. Epub 2018 Jul 5.

Department of Physiology and Pharmacology, Sackler School of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:

An identical sensory stimulus may or may not be incorporated into perceptual experience, depending on the behavioral and cognitive state of the organism. What determines whether a sensory stimulus will be perceived? While different behavioral and cognitive states may share a similar profile of electrophysiology, metabolism, and early sensory responses, neuromodulation is often different and therefore may constitute a key mechanism enabling perceptual awareness. Specifically, noradrenaline improves sensory responses, correlates with orienting toward behaviorally relevant stimuli, and is markedly reduced during sleep, while experience is largely "disconnected" from external events. Despite correlative evidence hinting at a relationship between noradrenaline and perception, causal evidence remains absent. Here, we pharmacologically down- and upregulated noradrenaline signaling in healthy volunteers using clonidine and reboxetine in double-blind placebo-controlled experiments, testing the effects on perceptual abilities and visually evoked electroencephalography (EEG) and fMRI responses. We found that detection sensitivity, discrimination accuracy, and subjective visibility change in accordance with noradrenaline (NE) levels, whereas decision bias (criterion) is not affected. Similarly, noradrenaline increases the consistency of EEG visually evoked potentials, while lower noradrenaline levels delay response components around 200 ms. Furthermore, blood-oxygen-level-dependent (BOLD) fMRI activations in high-order visual cortex selectively vary along with noradrenaline signaling. Taken together, these results point to noradrenaline as a key factor causally linking visual awareness to external world events. VIDEO ABSTRACT.

Abstract Video

Noradrenaline Modulates Visual Perception/ Curr. Biol., Jul. 5, 2018 (Vol. 28, Issue 14)


Source: Cell Press

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July 2018
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