Efficacy of Adjunctive Bioactive Materials in the Treatment of Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis.

Biomed Res Int 2018 27;2018:8670832. Epub 2018 May 27.

Department of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, China.

Objectives: Lots of bioactive materials have been additionally applied for the treatment of periodontal intrabony defect. However, there is dearth of studies to systematically evaluate the supplementary role of them in periodontal regeneration. The goal of this meta-analysis is to evaluate the adjunctive effects of bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) on the outcomes of bone grafting treatment for periodontal intrabony defects.

Methods: Articles published before December 2017 were searched electronically in three databases (PubMed, Embase, and Cochrane Central), with no date or language limits. Randomized controlled trials (RCTs) on the assessment of effectiveness of the four biomaterials in conjunction with demineralized freeze-dried bone allografts (DFDBA) in the treatment of periodontal intrabony defects were enrolled in this meta-analysis. Data were analyzed with STATA 12.

Results: Nine studies were included. PRF and PRP significantly improved pocket depth (PD) reduction and clinical attachment loss (CAL) gain. Only PRF exhibited a positive result in recession reduction (RecRed). Only PRP showed a statistically significant increase in bone fill. AM merely gained more CAL. EMD did not improve any clinical outcome.

Conclusion: Our data suggest that PRF/PRP could be taken as a preferred adjunct to facilitate periodontal regeneration of intrabony defects.

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Source
http://dx.doi.org/10.1155/2018/8670832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994283PMC
January 2019
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(Supplied by CrossRef)

Journal of Periodontology 2005

Journal of the Califomia Dental Association 2005

Journal of Clinical Periodontology 2004

Implantodontie 2001

International Journal of Science and Research (IJSR) 2016

Indian Journal of Medical Research 2014

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