Blood Coagul Fibrinolysis 2021 Feb 18. Epub 2021 Feb 18.
Pfizer Inc., Collegeville, Pennsylvania, USA Department of Pediatric Hematology, University of Ege, Izmir, Turkey Bartholomew J. Tortella and Marcus E. Carr are currently at Spark Therapeutics, Philadelphia, Pennsylvania, USA. Pablo Rendo is currently at Sanofi, Waltham, Massachusetts, USA.
In a pivotal, multicenter, open-label study, 25 patients aged 12-54 years with moderately severe/severe hemophilia B received on-demand nonacog alfa (6 months; dose at investigator's discretion) followed by once-weekly prophylaxis with nonacog alfa 100 IU/kg (12 months). During prophylaxis, patients had a median spontaneous annualized bleeding rate (sABR) of 1.0 and significant reductions in ABR (P < 0. Read More