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Blood Coagul Fibrinolysis 2021 Feb 18. Epub 2021 Feb 18.

Pfizer Inc., Collegeville, Pennsylvania, USA Department of Pediatric Hematology, University of Ege, Izmir, Turkey Bartholomew J. Tortella and Marcus E. Carr are currently at Spark Therapeutics, Philadelphia, Pennsylvania, USA. Pablo Rendo is currently at Sanofi, Waltham, Massachusetts, USA.

In a pivotal, multicenter, open-label study, 25 patients aged 12-54 years with moderately severe/severe hemophilia B received on-demand nonacog alfa (6 months; dose at investigator's discretion) followed by once-weekly prophylaxis with nonacog alfa 100 IU/kg (12 months). During prophylaxis, patients had a median spontaneous annualized bleeding rate (sABR) of 1.0 and significant reductions in ABR (P < 0. Read More

BJU Int 2021 Feb 25. Epub 2021 Feb 25.

Division of Urology, Hospital das Clínicas, University of Sao Paulo Medical School, Sao Paulo, Brazil.

Objectives: To assess the efficacy and safety of single-dose tranexamic acid on the blood transfusion rate and outcomes of patients with complex kidney stones who have undergone percutaneous nephrolithotomy (PCNL).

Material And Methods: In a randomized, double-blinded, placebo-controlled trial, 192 patients with complex kidney stone (Guy's Stone Scores III-IV) were prospectively enrolled and randomized (1:1 ratio) to receive either one dose of tranexamic acid (1 g) or a placebo at the time of anesthetic induction for PCNL. The primary outcome measure was the occurrence rate of perioperative blood transfusion. Read More

Ulus Travma Acil Cerrahi Derg 2021 Mar;27(2):161-166

University of Natural Sciences and Humanities, Faculty of Medical Sciences and Health Sciences, Siedlce-Poland.

Background: One of the most frequent life-threatening emergencies is extremity haemorrhage. In such cases, patient survival depends on a fast on-scene intervention. Thus, both the potential witnesses and medical emergency staff should have the ability to control haemorrhages. Read More

Cochrane Database Syst Rev 2021 Feb 25;2:CD012968. Epub 2021 Feb 25.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Background: Breast cancer is one of the most common cancers among women. Surgical removal of the cancer is the mainstay of treatment; however, tumour handling during surgery can cause microscopic dissemination of tumour cells and disease recurrence. The body's hormonal response to surgery (stress response) and general anaesthesia may suppress immunity, promoting tumour dissemination. Read More

Clin Oral Implants Res 2021 Feb 25. Epub 2021 Feb 25.

Department of Periodontics, University of Washington School of Dentistry, Seattle, WA, USA.

Objectives: The primary aim of this study was to investigate the relationship between interproximal open contacts and peri-implant disease. The secondary aim was to assess patient-reported outcome measures in relation to contact status.

Materials And Methods: A cross-sectional study was performed on 61 patients with 142 implants adjacent to at least one natural tooth. Read More