Layer I Interneurons Sharpen Sensory Maps during Neonatal Development.

Authors:
Alicia Che
Alicia Che
University of Connecticut
United States
Rachel Babij
Rachel Babij
Columbia University
United States
Conor Liston
Conor Liston
Sackler Institute for Developmental Psychobiology
United States
Gord Fishell
Gord Fishell
New York University Medical Center
United States

Neuron 2018 Jul 21;99(1):98-116.e7. Epub 2018 Jun 21.

Center for Neurogenetics, Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USA. Electronic address:

The neonatal mammal faces an array of sensory stimuli when diverse neuronal types have yet to form sensory maps. How these inputs interact with intrinsic neuronal activity to facilitate circuit assembly is not well understood. By using longitudinal calcium imaging in unanesthetized mouse pups, we show that layer I (LI) interneurons, delineated by co-expression of the 5HT3a serotonin receptor (5HT3aR) and reelin (Re), display spontaneous calcium transients with the highest degree of synchrony among cell types present in the superficial barrel cortex at postnatal day 6 (P6). 5HT3aR Re interneurons are activated by whisker stimulation during this period, and sensory deprivation induces decorrelation of their activity. Moreover, attenuation of thalamic inputs through knockdown of NMDA receptors (NMDARs) in these interneurons results in expansion of whisker responses, aberrant barrel map formation, and deficits in whisker-dependent behavior. These results indicate that recruitment of specific interneuron types during development is critical for adult somatosensory function. VIDEO ABSTRACT.

Abstract Video

Role of L1 Interneurons in Sensory Map Formation


Source: Cell Press

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http://dx.doi.org/10.1016/j.neuron.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152945PMC

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July 2018
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