Analysis of shared heritability in common disorders of the brain.

Authors:

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018
146 Reads
7 Citations
31.480 Impact Factor

Publication Analysis

Top Keywords

brain disorders
12
disorders brain
8
disorders
8
psychiatric disorders
8
brain
5
identified sharing
4
appear distinct
4
distinct psychiatric
4
disorders identified
4
sharing disorders
4
phenotypes including
4
including cognitive
4
brain phenotypes
4
number brain
4
disorders number
4
disorders appear
4
common variant
4
phenotypes 1191588
4
relationship phenotypes
4
assessed relationship
4

References

(Supplied by CrossRef)

Similar Publications