α-Catenin Controls the Anisotropy of Force Distribution at Cell-Cell Junctions during Collective Cell Migration.

Authors:
Kenji Matsuzawa
Kenji Matsuzawa
Nagoya University Graduate School of Medicine
Japan
Takuya Himoto
Takuya Himoto
Kyushu University
Yuki Mochizuki
Yuki Mochizuki
Graduate School of Science and Engineering
Los Angeles | United States
Junichi Ikenouchi
Junichi Ikenouchi
Kyoto University

Cell Rep 2018 Jun;23(12):3447-3456

Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka 819-0395, Japan; AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan. Electronic address:

Adherens junctions (AJs) control epithelial cell behavior, such as collective movement and morphological changes, during development and in disease. However, the molecular mechanism of AJ remodeling remains incompletely understood. Here, we report that the conformational activation of α-catenin is the key event in the dynamic regulation of AJ remodeling. α-catenin activates RhoA to increase actomyosin contractility at cell-cell junctions. This leads to the stabilization of activated α-catenin, in part through the recruitment of the actin-binding proteins, vinculin and afadin. In this way, α-catenin regulates force sensing, as well as force transmission, through a Rho-mediated feedback mechanism. We further show that this is important for stable directional alignment of multiple cells during collective cell movement by both experimental observation and mathematical modeling. Taken together, our findings demonstrate that α-catenin controls the establishment of anisotropic force distribution at cell junctions to enable cooperative movement of the epithelial cell sheet.

Abstract Video

?-catenin in collective cell migration


Source: Cell Press

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http://dx.doi.org/10.1016/j.celrep.2018.05.070DOI Listing

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June 2018
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