Possible roles of basophils in chronic itch.

Authors:
Takashi Hashimoto
Takashi Hashimoto
Kurume University Institute of Cutaneous Cell Biology
Kurume | Japan
Jordan D Rosen
Jordan D Rosen
Leonard M. Miller School of Medicine
Kristen M Sanders
Kristen M Sanders
Lewis Katz School of Medicine
Philadelphia | United States
Gil Yosipovitch
Gil Yosipovitch
Miller School of Medicine
Miami | United States

Exp Dermatol 2018 Jun 12. Epub 2018 Jun 12.

Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.

Basophils are blood granulocytes and normally constitute <1% of blood peripheral leucocytes. Basophils share some morphological and functional similarities with mast cells, and basophils were once regarded as redundant and negligible circulating mast cells. However, recent studies reveal the indispensable roles of basophils in various diseases, including allergic and pruritic diseases. Basophils may be involved in itch through the mediation of a Th2 immune response, interaction with other cells in the skin and secretion of a wide variety of itch-related mediators, for example histamine, cytokines and chemokines (IL-4, IL-13, IL-31 and TSLP), proteases (cathepsin S), prostaglandins (PGE2 and PGD2), substance P and platelet-activating factor. Not only pruritic skin diseases (eg, atopic dermatitis, irritant contact dermatitis, chronic urticaria, prurigo, papulo-erythroderma of Ofuji, eosinophilic pustular folliculitis, scabies, tick bites and bullous pemphigoid) but also pruritic systemic diseases (eg, primary sclerosing cholangitis and polycythemia vera) may be affected by basophils.

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http://dx.doi.org/10.1111/exd.13705DOI Listing
June 2018
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