Top-down feedback controls spatial summation and response amplitude in primate visual cortex.

Nat Commun 2018 06 11;9(1):2281. Epub 2018 Jun 11.

Department of Ophthalmology and Visual Science, Moran Eye Institute, University of Utah, 65 Mario Capecchi Drive, Salt Lake City, UT, 84132, USA.

Sensory information travels along feedforward connections through a hierarchy of cortical areas, which, in turn, send feedback connections to lower-order areas. Feedback has been implicated in attention, expectation, and sensory context, but the mechanisms underlying these diverse feedback functions are unknown. Using specific optogenetic inactivation of feedback connections from the secondary visual area (V2), we show how feedback affects neural responses in the primate primary visual cortex (V1). Reducing feedback activity increases V1 cells' receptive field (RF) size, decreases their responses to stimuli confined to the RF, and increases their responses to stimuli extending into the proximal surround, therefore reducing surround suppression. Moreover, stronger reduction of V2 feedback activity leads to progressive increase in RF size and decrease in response amplitude, an effect predicted by a recurrent network model. Our results indicate that feedback modulates RF size, surround suppression and response amplitude, similar to the modulatory effects of visual spatial attention.

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http://dx.doi.org/10.1038/s41467-018-04500-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995810PMC
June 2018
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References

(Supplied by CrossRef)

DC Essen Van et al.
Trends Neurosci. 1983

CJ McAdams et al.
J. Neurosci. 2005

SJ Luck et al.
J. Neurophysiol. 1997

RP Rao et al.
Nat. Neurosci. 1999

A Angelucci et al.
Prog. Brain. Res. 2006

CJ McAdams et al.
J. Neurosci. 1999

KA Sundberg et al.
Neuron 2009

MJ Roberts et al.
Nat. Neurosci. 2007

S Shushruth et al.
J. Neurophysiol. 2009

J Allman et al.
Ann. Rev. Neurosci. 1985

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