Immune checkpoint failures in inflammatory myopathies: An overview.

Sandrine Herbelet, Jan L De Bleecker

Summary

Not all immune checkpoint failures hav ebeen explored in myositis. This review provides new research ideas.

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Immune checkpoint failures in inflammatory myopathies: An overview.

Authors:
dr Sandrine Herbelet, DVM
dr Sandrine Herbelet, DVM
Ghent University/ Ghent University Hospital
dr
myositis, resuscitation
9000 GENT | Belgium

Autoimmun Rev 2018 Aug 6;17(8):746-754. Epub 2018 Jun 6.

Department of Neurology, Ghent University and Ghent University Hospital, C. Heymanslaan 10, 9000 Gent, Belgium.

Dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM), immune mediated necrotizing myopathy (IMNM) and overlap myositis (OM) are classified as inflammatory myopathies (IM) with involvement of autoimmune features such as autoreactive lymphocytes and autoantibodies. Autoimmunity can be defined as a loss in self-tolerance and attack of autoantigens by the immune system. Self-tolerance is achieved by a group of immune mechanisms occurring in central and periphal lymphoid organs and tissues, called immune checkpoints, that work in synergy to protect the body from harmful immune reactions. Autoimmune disorders appear when immune checkpoints fail. In this review, the different immune checkpoint failures are discussed in DM, PM, IBM and IMNM. Exploring research contribution in each of these immune checkpoints might help to highlight research perspectives in the field and obtain a more complete picture of IM disease pathology.

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Source
http://dx.doi.org/10.1016/j.autrev.2018.01.026DOI Listing
August 2018
14 Reads
7.933 Impact Factor

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