Association between urinary tin concentration and diabetes in nationally representative sample of US adults.

J Diabetes 2018 Dec 4;10(12):977-983. Epub 2018 Jul 4.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.

Background: Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults.

Methods: We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n = 605) was defined as self-reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs).

Results: Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; P  = 0.02).

Conclusions: Environmental tin exposure was positively and significantly associated with diabetes in US adults.

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Source
http://doi.wiley.com/10.1111/1753-0407.12798
Publisher Site
http://dx.doi.org/10.1111/1753-0407.12798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218306PMC
December 2018
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References

(Supplied by CrossRef)
Economic costs of diabetes in the U.S. in 2012
American Diabetes Association et al.
Diabetes Care 2013
Endocrine disruptors in the etiology of type 2 diabetes mellitus
Alonso-Magdalena et al.
Nat Rev Endocrinol 2011

The U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry et al.
2005

Howe et al.
2005

Agency for Toxic Substances and Disease Registry et al.
2005

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