Proof-of-Concept Study for an Enhanced Surrogate Marker of Endothelial Function in Diabetes.

Sci Rep 2018 06 5;8(1):8649. Epub 2018 Jun 5.

Nanyang Polytechnic, School of Engineering, Singapore, Singapore.

Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distensibility of a distal vessel should be a good biomarker for subclinical disease. We have developed a device capable of measuring reactive hyperaemia induced changes in the radial artery flow, volumetric changes and accompanying effects on the vessel wall. The measurement is based on the magnetic flux disturbance upon haemodynamic modulation as blood flows through a uniformly applied magnetic field, and generates what we have termed the radial artery maximum distensibility index (RA-MDI). In a proof-of-concept study we found significant correlations between RA-MDI and cardiovascular risk factors, scoring systems and carotid artery intima-media thickness. Further large scale prospective studies need to be conducted to ascertain the correlations with cardiovascular events.

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A new method for tracking endothelial dysfunction and heart disease risk in patients with diabetes


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http://dx.doi.org/10.1038/s41598-018-26931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988679PMC
June 2018
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References

(Supplied by CrossRef)

K Yahagi et al.
Arterioscler Thromb Vasc Biol. 2017

DS Celermajer et al.
Lancet. 1992

KG Reddy et al.
J Am Coll Cardiol. 1994

BM Balletshofer et al.
Circulation. 2000

AE Caballero et al.
Diabetes. 1999

M Tesauro et al.
Metabolism. 2007

R Furchgott et al.
Nature Lond. 1980

DS Celermajer et al.
J Am Coll Cardiol. 1994

J Deanfield et al.
J Hypertens. 2005

AJ Flammer et al.
Circulation. 2012

MT Johnstone et al.
Circulation. 1993

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