Proof-of-Concept Study for an Enhanced Surrogate Marker of Endothelial Function in Diabetes.

Authors:
S Goh
S Goh
Fairfield Hospital
Australia
Sun Bing
Sun Bing
Fudan University
China

Sci Rep 2018 Jun 5;8(1):8649. Epub 2018 Jun 5.

Nanyang Polytechnic, School of Engineering, Singapore, Singapore.

Diabetes mellitus affects distal small vessels earlier and to a greater extent than proximal vessels. Vascular disease starts from activation of the endothelial cells, which if prolonged may lead to reduced distensibility of the vessel when maximally stimulated. Hence a device which measures distensibility of a distal vessel should be a good biomarker for subclinical disease. We have developed a device capable of measuring reactive hyperaemia induced changes in the radial artery flow, volumetric changes and accompanying effects on the vessel wall. The measurement is based on the magnetic flux disturbance upon haemodynamic modulation as blood flows through a uniformly applied magnetic field, and generates what we have termed the radial artery maximum distensibility index (RA-MDI). In a proof-of-concept study we found significant correlations between RA-MDI and cardiovascular risk factors, scoring systems and carotid artery intima-media thickness. Further large scale prospective studies need to be conducted to ascertain the correlations with cardiovascular events.

Abstract Video

A new method for tracking endothelial dysfunction and heart disease risk in patients with diabetes


Source: Research Square

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-26931-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988679PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
June 2018
172 Reads

Publication Analysis

Top Keywords

proof-of-concept study
8
radial artery
8
vessel wall
4
wall measurement
4
effects vessel
4
accompanying effects
4
measurement based
4
changes accompanying
4
magnetic flux
4
modulation blood
4
blood flows
4
haemodynamic modulation
4
disturbance haemodynamic
4
volumetric changes
4
flux disturbance
4
based magnetic
4
artery flow
4
disease developed
4
developed device
4
subclinical disease
4

Similar Publications