Burden of non-alcoholic fatty liver disease in Australia.

J Gastroenterol Hepatol 2018 Jun;33 Suppl 1:1-11

Medical School, University of Western Australia, Nedlands, Western Australia, Australia.

Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease in the Australian population, although precise estimates of prevalence are lacking. NAFLD may progress to liver fibrosis, cirrhosis, decompensated liver disease, and liver cancer and is becoming an increasingly common indication for liver transplantation in Australia and New Zealand. There is an extrahepatic burden of NAFLD extending beyond the liver, which is manifested by an increased risk of developing cardiovascular disease, diabetes, and chronic renal impairment, all of which are common causes of morbidity in the Australian population. Early recognition of those patients at high risk of developing advanced liver disease is essential in order to target those who will benefit from intensive lifestyle modification. In this review, we present data on the epidemiology of NAFLD within Australia, its associated health burden in terms of hepatic and extrahepatic complications, common clinical presentations, and indications for treatment. We also propose a research agenda that highlights knowledge needed to improve diagnosis and management specific to the Australian context.

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14270DOI Listing
June 2018
6 Reads

Publication Analysis

Top Keywords

liver disease
20
liver
9
fatty liver
8
australian population
8
risk developing
8
non-alcoholic fatty
8
disease
6
advanced liver
4
developing advanced
4
lifestyle modification
4
patients high
4
disease essential
4
high risk
4
order target
4
benefit intensive
4
intensive lifestyle
4
recognition patients
4
will benefit
4
target will
4
essential order
4

References

(Supplied by CrossRef)
Evaluating feasibility and accuracy of non-invasive tests for nonalcoholic fatty liver disease in severe and morbid obesity
Ooi et al.
Int. J. Obes. (Lond) 2018

Similar Publications