Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity.

Genome Announc 2018 May 24;6(21). Epub 2018 May 24.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Here, we report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. Paired comparisons of the 13,335-nucleotide genomes revealed that the virus acquired the T10736C transition in its genome, which did not affect the amino acid sequences of HMPV proteins.

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Source
http://dx.doi.org/10.1128/genomeA.00440-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968720PMC
May 2018

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