Activity of Clofazimine against Nontuberculous Mycobacteria Isolated in Beijing, China.

Antimicrob Agents Chemother 2018 07 26;62(7). Epub 2018 Jun 26.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China

Due to the natural resistance of nontuberculous mycobacteria (NTM) to many antibiotics, the treatment of diseases caused by NTM is often long-term but unsuccessful. The main goal of this study was to evaluate the susceptibilities to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing, China. Furthermore, 47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium (SGM) species. The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well. Clofazimine exhibited excellent activity against both reference strains and clinical isolates of different SGM species, and most of the strains had MICs far below 1 μg/ml. Although the majority of the clinical isolates of and had MICs higher than 2 μg/ml, 17 out of the 30 reference strains of different RGM species had MICs below 1 μg/ml According to the MIC distributions, the tentative epidemiological cutoff (ECOFF) values for , , and were defined at 0.5 μg/ml, 1 μg/ml, and 2 μg/ml, respectively. Intriguingly, single-direction cross-resistance between bedaquiline- and clofazimine (Cfz)-resistant isolates was observed among the tested NTM species. This study demonstrates that clofazimine had strong activity against most SGM species , as well as some RGM species. The data provide important insights into the possible clinical application of Cfz to treat NTM infections.

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00072-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021646PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
July 2018
13 Reads

Publication Analysis

Top Keywords

sgm species
12
reference strains
12
rgm species
12
μg/ml μg/ml
8
beijing china
8
clinical isolates
8
ntm species
8
species
8
isolated beijing
8
growing mycobacterium
8
nontuberculous mycobacteria
8
mics μg/ml
8
ntm
6
μg/ml
6
clofazimine
5
clofazimine exhibited
4
well clofazimine
4
clofazimine strong
4
exhibited excellent
4
isolates sgm
4

References

(Supplied by CrossRef)

Similar Publications