Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease.

Turk J Gastroenterol 2018 03;29(2):170-176

Armed Forces Institute of Radiology, National University of Medical Sciences, Islamabad Pakistan.

Background/aims: Non-alcoholic fatty liver disease (NAFLD) is a growing public health problem worldwide and is associated with increased morbidity and mortality. Currently, there is no definitive treatment for this disease. ?-Tocotrienol has potent anti-inflammatory and antioxidant properties and may reduce liver injury in NAFLD. The present study aims to evaluate the efficacy and safety of ?-tocotrienol in the treatment of NAFLD.

Materials And Methods: The present study was a randomized, double-blind, placebo-controlled pilot study conducted in patients aged > 20 years, belonging to both sexes, having ultrasound-proven fatty liver disease, having a fatty liver index (FLI) of ? 60, and persistent elevation of alanine transaminase. A total of 71 patients were assigned to receive either oral ?-tocotrienol (n=35, 300 mg twice daily) or placebo (n=36) for 12 weeks. At the baseline and at the end of the study, clinical and biochemical parameters, including lipid profile, liver function tests, high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were measured. Body mass index and FLI were calculated, and ultrasound grading of hepatic steatosis was performed.

Results: Out of 71 enrolled patients, 64 patients, 31 in the ?-tocotrienol group and 33 in the placebo group, completed the study. After 12 weeks of supplementation, ?-tocotrienol showed greater efficacy than placebo by decreasing serum aminotransferases, hs-CRP, MDA, and FLI score (p<0.001). However, it did not improve hepatic steatosis on ultrasound examination. No adverse effects were reported.

Conclusion: ?-Tocotrienol was safe, and it effectively improved aminotransferase levels and inflammatory and oxidative stress markers in patients with NAFLD. Large-scale randomized clinical trials are warranted to further support these findings.

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Source
http://dx.doi.org/10.5152/tjg.2018.17297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284694PMC
March 2018
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