Endobronchial Ultrasound Elastography Differentiates Intrathoracic Lymph Nodes: A Meta-Analysis.

Ann Thorac Surg 2018 10 5;106(4):1251-1257. Epub 2018 May 5.

Department of Pulmonary Medicine, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China. Electronic address:

Background: In this study, we investigated the clinical significance of endobronchial ultrasound elastography for differentiating malignant and benign intrathoracic lymph nodes.

Methods: A meta-analysis was performed to evaluate the sensitivity and specificity of endobronchial ultrasound elastography in diagnosing intrathoracic lymph nodes. Publications before October 1, 2017, were included for analysis. Sensitivity, specificity, and other variables were pooled using the bivariate mixed-effects regression model.

Results: Seven studies met the inclusion criteria and were included. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio was 0.93 (95% confidence interval [CI], 0.85 to 0.97), 0.85 (95% CI, 0.78 to 0.90), 6.3 (95% CI, 4.2 to 9.2), 0.08 (95% CI, 0.04 to 0.18), and 74 (95% CI, 33 to 168), respectively. The summary receiver operating characteristic curve was 0.93 (95% CI, 0.91 to 0.95).

Conclusions: The results revealed endobronchial ultrasound elastography is a new technique with high sensitivity and specificity. It has a fine performance in diagnosing intrathoracic lymph nodes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.athoracsur.2018.04.003DOI Listing
October 2018
3 Reads

Publication Analysis

Top Keywords

sensitivity specificity
16
ultrasound elastography
16
intrathoracic lymph
16
endobronchial ultrasound
16
lymph nodes
12
likelihood ratio
8
diagnosing intrathoracic
8
093 95%
8
95%
6
studies met
4
097 085
4
operating characteristic
4
mixed-effects regression
4
regression modelresults
4
085 95%
4
bivariate mixed-effects
4
met inclusion
4
receiver operating
4
modelresults studies
4
variables pooled
4

Similar Publications