Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)-Two-Year Follow-Up Study.

Int J Endocrinol 2018 15;2018:7631659. Epub 2018 Mar 15.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Aim/introduction: This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU).

Materials And Methods: In this prospective cohort study in a university hospital, all the participants were examined and followed up for new DFU as final outcome for two years. To analyze the data, the variables were first evaluated with a univariate analysis. Then variables with value < 0.2 were tested with a multivariate analysis, using backward-elimination multiple logistic regression.

Results: Among 605 patients, 39 cases had DFU, so we followed up the remaining 566 patients without any present or history of DFU. A two-year cumulative incidence of diabetic foot ulcer was 5.62% (95% CI 3.89-8.02). After analysis, previous history of DFU or amputation [OR = 9.65, 95% CI (2.13-43.78), value = 0.003], insulin usage [OR = 5.78, 95% CI (2.37-14.07), value < 0.01], gender [OR = 3.23, 95% CI (1.33-7.83), value = 0.01], distal neuropathy [OR = 3.37, 95% CI (1.40-8.09), value = 0.007], and foot deformity [OR = 3.02, 95% CI (1.10-8.29), value = 0.032] had a statistically significant relationship with DFU incidence.

Conclusion: Our data showed that the average annual DFU incidence is about 2.8%. Independent risk factors of DFU development were previous history of DFU or amputation, insulin consumption, gender, distal neuropathy, and foot deformity. These findings provide support for a multifactorial etiology for DFU.

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Source
http://dx.doi.org/10.1155/2018/7631659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875034PMC
March 2018

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