Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Mar;43(3):313-319
Life Science Institute, Guangxi Medical University, Nanning 530021, China.
Hepatic fibrosis is a repair response to liver injury, and hepatic stellate cell activation is the center of hepatic fibrosis, which involves Hippo, Notch, Wnt/β-catenin, and TGF-β/Smad signaling pathways. YAP/TAZ is an important nucleus factor for Hippo tumor suppressor pathway and its activity is the key to the growth of whole organs, cell proliferation, and specific amplification of progenitor cells in the process of tissue renewal and regeneration. As the hub of signaling pathways, such as Hippo, Notch, Wnt/β-catenin, TGF-β/Smad signaling, YAP/TAZ regulates the genesis and development of liver fibrosis.