Case Rep Genet 2018 22;2018:6968395. Epub 2018 Feb 22.
Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, USA.
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Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:70-72
Urticaria, also known as hives, may affect up to 20% of the population at some time in their lives. Urticaria is characterized by extreme pruritus and described as erythematous, raised, circumscribed lesions with central pallor that blanch with pressure. The pathogenesis of urticaria involves mast cell activation, with subsequent release of histamine and other vasoactive mediators, leading to increased vascular permeability of postcapillary venules and development of edema, erythema, and pruritus. Read More
Eur Ann Allergy Clin Immunol 2008 May;40(1):5-13
Department of Pediatrics, University of Florence, Italy.
Urticaria is a rash, that typically involves skin and mucosa, and is characterized by lesions known as hives or wheals. In some cases there is an involvement of deep dermis and subcutaneous tissue that causes a skin/mucosa manifestation called angioedema. Urticaria and angioedema are very often associated: urticaria-angioedema syndrome. Read More
Ann Allergy Asthma Immunol 2000 Aug;85(2):156-7
Caduti Bollatesi Hospital, Milan, Italy.
Background: About 30% of patients with chronic urticaria experience flares of hives and/or angioedema after ingesting either aspirin or nonsteroidal anti-inflammatory drugs. In such patients, cross-reactivity to all NSAIDs seems to occur suggesting a mechanism dependent on cyclooxygenase inhibition.
Objective: To evaluate the preventive effect of leukotriene receptor antagonists on urticaria exacerbations induced by NSAIDs in a patient with chronic urticaria. Read More
Presse Med 2015 Jan 18;44(1):37-42. Epub 2014 Dec 18.
Hospices civils de Lyon, centre hospitalier Lyon-Sud, service d'allergologie et d'immunologie clinique, 69495 Pierre-Bénite, France; Inserm U1111-CIRI/UMS3444/US8, 21, avenue Tony-Garnier, 69007 Lyon, France; Université Claude-Bernard Lyon I, UFR médecine Lyon-Sud Charles-Mérieux, 69921 Oullins cedex, France. Electronic address:
Most angioedemas are histaminergic and correspond to deep urticarial swelling. Recurrent histaminergic angioedema led to the diagnosis of chronic urticaria, even when there are no superficial associated hives. Chronic urticaria is a benign disease, and autoimmune in 40 % of cases. Read More