Anticancer effects of soybean-derived peptides.

Saleha B Vuyyuri, Chris Shidal, Keith R Davis

Overview

The soy-derived peptide Lunasin has been shown to have significant chemopreventive and therapeutic effects on a variety of cancer cell types in preclinical studies. This review focuses on the potential mechanisms of action of Lunasin and the intriguing and potentially groundbreaking discovery that Lunasin may have the ability to target cancer stem cells.

Summary

There is a clear need for improved cancer therapies with increased efficacy and fewer side effects. Lunasin's ability to target key signalling pathways required for metastasis and its effects on cancer stem cells make it a potential candidate as a powerful adjuvant therapy that can be coupled with new targeted immunotherapies.

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Author Comments

Dr. Keith R Davis, Ph.D.
Dr. Keith R Davis, Ph.D.
SativaGen, Inc
Co-Founder and VP of Plant Research
Bloomington, Indiana | United States
Although Lunasin's anticancer activity was first discovered over twenty years ago, it has not received the attention it deserves given its broad activity against many cancer types and its potential chemoprevention use. Further research is needed to move Lunasin into a drug development program that will create formulations with increased bioavailability and test clinical efficacy.Dr. Keith R Davis, Ph.D.

Resources

Development of the plant-derived peptide lunasin as an anticancer agent.

Authors:
Dr. Keith R Davis, Ph.D.
Dr. Keith R Davis, Ph.D.
SativaGen, Inc
Co-Founder and VP of Plant Research
Bloomington, Indiana | United States

Curr Opin Pharmacol 2018 08 22;41:27-33. Epub 2018 May 22.

Biotechnology Program, Department of Biology, Indiana University, Bloomington, IN, USA; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA. Electronic address:

The health benefits of soy consumption have long been recognized. An important potential benefit is the linkage of soy consumption with reduced cancer risk. One emerging factor that may confer the anticancer effects of soy is the peptide lunasin. Lunasin has both chemopreventive and therapeutic activities against a variety of carcinogens and cancer types. A novel feature of lunasin is that it contains multiple functional domains that can modulate gene expression through effects on histone acetylation and integrin signaling. Recent studies suggest that lunasin effects on integrin signaling in cancer stem cells reduce expression of stemness factors with a concomitant reduction in metastatic potential. Here, we highlight recent studies of the potential use of lunasin as an anticancer agent and its mode of action.

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http://dx.doi.org/10.1016/j.coph.2018.04.006DOI Listing
August 2018
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