The soy-derived peptide Lunasin has been shown to have significant chemopreventive and therapeutic effects on a variety of cancer cell types in preclinical studies. This review focuses on the potential mechanisms of action of Lunasin and the intriguing and potentially groundbreaking discovery that Lunasin may have the ability to target cancer stem cells.
There is a clear need for improved cancer therapies with increased efficacy and fewer side effects. Lunasin's ability to target key signalling pathways required for metastasis and its effects on cancer stem cells make it a potential candidate as a powerful adjuvant therapy that can be coupled with new targeted immunotherapies.
Although Lunasin's anticancer activity was first discovered over twenty years ago, it has not received the attention it deserves given its broad activity against many cancer types and its potential chemoprevention use. Further research is needed to move Lunasin into a drug development program that will create formulations with increased bioavailability and test clinical efficacy.Dr. Keith R Davis, Ph.D.
Curr Opin Pharmacol 2018 08 22;41:27-33. Epub 2018 May 22.
Biotechnology Program, Department of Biology, Indiana University, Bloomington, IN, USA; Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN, USA. Electronic address:
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