Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (, , , and ) Genes with Preeclampsia.

Dis Markers 2018 18;2018:1371425. Epub 2018 Feb 18.

Department of Medical Biotechnology, Medical University of Lodz, Łódź, Poland.

Background: Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation process may influence the development of preeclampsia.

Methods: Blood samples were collected from 86 mothers and 86 children after preeclampsia and 85 mothers and 85 children with uncomplicated pregnancies. The distribution of genotypes for -1607 1G/2G , -735 C/T , -1306 C/T , -1171 5A/6A , and -1562C/T polymorphisms was determined by RFLP-PCR.

Results: The occurrence of 1G/1G or 5A/5A genotype in the mother or 1G/1G or 5A/6A genotype in the child is associated with preeclampsia development. Moreover, simultaneous maternal and fetal 1G/1G homozygosity increases the risk of preeclampsia development 2.39-fold and the set of maternal 5A/5A and fetal 5A/6A genotypes by over 4.5 times. No association between the carriage of studied or polymorphisms and the predisposition to preeclampsia was found.

Conclusion: The maternal 1G/1G and 5A/5A and fetal 1G/1G and 5A/6A gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

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