Cardiac eccentric remodeling in patients with rheumatoid arthritis.

Authors:
Rosa Finelli
Rosa Finelli
University of Salerno
Fisciano | Italy
Enrico Coscioni
Enrico Coscioni
San Giovanni di Dio e Ruggì D'Aragona Hospital
Raffaele Izzo
Raffaele Izzo
Hypertension Research Center
Winston-Salem | United States
Francesco Rozza
Francesco Rozza
University of Salerno
Fisciano | Italy

Sci Rep 2018 Apr 12;8(1):5867. Epub 2018 Apr 12.

Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

It is known that patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease and sudden cardiac death. Abnormalities in cardiac geometry appear to be involved in the setting of the cardiovascular risk, but it has never been specifically investigated in RA. We enrolled 44 patients with RA compared to 131 subjects without RA (normal, N): The RA aged between 18 and 70 years (mean 48.3 ± 2.1), 25 females, BMI 27.6 ± 0.9; N, of equal age (48.6 ± 1.2, n.s.), included 80 females (BMI 26.7 ± 0.2, ns). Cardiac Ultrasounds showed an increase of the diameter of the left ventricle but not in the septum with reduction of relative wall thickness (RWT) in the RA population compared to N. Relative wall thickness inversely correlates with biochemical parameters of inflammatory response (gamma globulin, p < 0.03; F = 5,660) and anti citrullinated peptides antibody (anti-CCP Ab) (p < 0.02; F = 7,1620) We conclude that unfavorable cardiac remodeling can increase cardiovascular risk in patients with RA.

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http://dx.doi.org/10.1038/s41598-018-24323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897374PMC

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