Neuroscience 2018 Apr 7. Epub 2018 Apr 7.
Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands.
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Brain 2017 Nov;140(11):2912-2926
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis; however, its underlying pathophysiological mechanisms, including its link to inflammatory demyelination and temporal occurrence in the disease course are still unknown. We used ultra-high field (7 T), ultra-high gradient strength diffusion and T1/T2-weighted myelin-sensitive magnetic resonance imaging to characterize microstructural changes in myelin and neuroaxonal integrity in the cortex and white matter in early stage multiple sclerosis, their distribution in lesional and normal-appearing tissue, and their correlations with neurological disability. Twenty-six early stage multiple sclerosis subjects (disease duration ≤5 years) and 24 age-matched healthy controls underwent 7 T T2*-weighted imaging for cortical lesion segmentation and 3 T T1/T2-weighted myelin-sensitive imaging and neurite orientation dispersion and density imaging for assessing microstructural myelin, axonal and dendrite integrity in lesional and normal-appearing tissue of the cortex and the white matter. Read More
Neuroimage Clin 2017 17;15:333-342. Epub 2017 May 17.
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Introduction: There is a need to develop imaging methods sensitive to axonal injury in multiple sclerosis (MS), given the prominent impact of axonal pathology on disability and outcome. Advanced multi-compartmental diffusion models offer novel indices sensitive to white matter microstructure. One such model, neurite orientation dispersion and density imaging (NODDI), is sensitive to neurite morphology, providing indices of apparent volume fractions of axons (v), isotropic water (v) and the dispersion of fibers about a central axis (orientation dispersion index, ODI). Read More
Neuroimage Clin 2014 13;4:649-58. Epub 2014 Apr 13.
Department of Imaging & Pathology, KU Leuven, Herestraat 49, Leuven 3000, Belgium ; Department of Radiology, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium ; Medical Imaging Research Center (MIRC), Herestraat 49, Leuven 3000, Belgium ; Leuven Research Institute for Neuroscience & Disease (LIND), Herestraat 49, Leuven 3000, Belgium.
Introduction: The histopathological basis of "unidentified bright objects" (UBOs) (hyperintense regions seen on T2-weighted magnetic resonance (MR) brain scans in neurofibromatosis-1 (NF1)) remains unclear. New in vivo MRI-based techniques (multi-exponential T2 relaxation (MET2) and diffusion MR imaging (dMRI)) provide measures relating to microstructural change. We combined these methods and present previously unreported data on in vivo UBO microstructure in NF1. Read More
Conf Proc IEEE Eng Med Biol Soc 2017 07;2017:3024-3027
Conventional diffusion-weighted MR imaging techniques provide limited specificity in disentangling disease-related microstructural alterations involving changes in both axonal density and myelination. By simultaneously probing multiple diffusion regimens, multi-shell diffusion MRI is capable of increasing specificity to different tissue sub-compartments and hence separate different contributions to changes in diffusion-weighted signal attenuation. Advanced multi-shell diffusion models impose significant requirements on the amount of diffusion weighting (i. Read More